Deb, my friend Karen just got in from Amsterdam, and here's her response:
There are distinct areas of AMS, and they're very easy to get to using the trams. The Museum District is where -- surprise! -- Rijksmuseum and Van Gogh are, and the street that's so similar to Rodeo Drive that's fun to window shop in. Also some arty, tony little cafes for a coffee or tea break or a simple lunch and people watch.
The Nine Streets is a famous district that's very nice and canal-y

and has some excellent shopping. Again, it's upscale.
The Jordaan is the AMS version of Greenwich Village. Quirky and fun. Tell her to Google.
That oughta get her started.