I felt I would post this here first because of everyone's kind recommendations. Robin, please feel free to move it to the travel section when you think it's appropriate.
I could write a book (or at least a very lengthy article) about our dining experiences in San Fran, but I think I'll just give a quick (relatively. . .) breakdown. If anyone wants any more information, please PM or respond here, and I'm happy to share.
Friday, June 12: On our second day in the Bay, we had dinner at Boulevard (http://www.boulevardrestaurant.com/). The food was outstanding, as was the wine selection. The restaurant was rather large, with three distinct dining areas; (1) the tables close to the bar had an upscale casual, bustling feel, (2) the long bar area that overlooked the kitchen had a modern, casual feel, and (3) the back area had a much more formal feel. We loved it, from the food to the location to the service.
Sunday, June 14: Dim Sum for an early dinner at Tan Kiang. What can I say? Best dim sum ever, though parking was a NIGHTMARE. I believe it was Carla that recommended this spot, BUT we went on the recommendation of my local Philipino tito-in-law before I even checked Carla's ideas. I'll add that I agree with both of them.
Tuesday, June 16: Day trip to wine country. We had lunch at Bouchon (http://www.bouchonbistro.com/) and had a great croque madame served with a mound of fantastic frites, with some haricot verts on the side. Immediately after we walked the two blocks down to French Laundry and had my picture taken outside. . .so. . .I. . .sorta went there. . . We followed this up with tastings at Girard, Peju, and Cakebread Cellars. I really liked the Girard wines, with the Cakebread lineup a close second (I've always been a fan of the Chardonnay, but the reds were tasty as well). Peju was so-so.
Wednesday, June 17: Early dinner at the Fog City Diner (http://www.fogcitydiner.com/) after strolling along the Embarcadero. We weren't that hungry, so we split the smoked chicken and three cheese chipotle quesadilla and macaroni and gouda cheese with black forest ham and sweet peas. The food was excellent, and the decor of that old style diner was amazing. Everything was very well priced as well. Their drink menu was interesting, and their curious take on a gin fizz was quite refreshing.
Thursday, June 18: We had dinner at the Slanted Door (http://www.slanteddoor.com/). This is a "modern Vietnamese" (read fusion) restaurant in the Ferry Building. It was rather large, loud, and bustling, but we were in the mood for that atmosphere so it worked. The hostess was rather surly, but otherwise service was great, especially the bartender as we waited for our table. I started with a half-dozen crazy good Shigoku oysters, and my wife had the squash blossom and dungeness crab soup. We split some spring rolls (shrimp, pork, mint, and peanut sauce), and followed that up with the wood oven roasted whole branzino with spicy gingered fish sauce. My wife isn't a great fan of whole fish, but she consented as it was nearly my birthday. I thought it was wonderful--slightly flaky, with a rich flavor that went well with the tangy, spicy fish sauce. Having been "wined-out" from our recent trip to Napa, we opted for the Frémont Cidre Brut "Greniers." This matched with the fish very well. Too stuffed for dessert, we each had a Vietnamese coffee to finish.
Friday, June 19: We had lunch at A16 (http://www.a16sf.com/), splitting the romaine and chicory salad with lemon and olive oil and the Margherita pizza (tomato, mozzarella, grana padano, basil, olive oil), and toasting with a nice, very dry Prosecco. I highly recommend this place (as if my acclaim adds anything to the plethora of accolades the restaurant and its chef have already received). The surrounding neighborhood provided a good after-lunch stroll.
That evening, we attended a wedding ceremony between two Indian friends. It was very large gathering at the bride's parent's house in the Alamo hills, and the catered Indian food was probably the best I've ever had. Just outstanding.
Saturday, June 20: We had a leisurely birthday lunch at Cafe de la Presse, a nice French joint run by the same folks that run Aqua (http://www.aqua-sf.com/cdlp/). The shared salade de laitue and confit de canard got our day started right. That evening, the reception for the previous evening's wedding was held at SF City Hall, and again was catered with amazing Indian food (and the 200+ Indians in the room agreed. . .).
Bottom line - we ate well. Very well. San Francisco has a fantastic dining scene, to be sure.