We moved here from Charlotte. What kind of a place are you looking for and what part of town will you be in?
My favorite place is Lulu -- it's a French Bistro that uses seasonal food. It's on Central Ave (in an old house) in the Plaza-Midwood neighborhood.
http://www.360charlotte.com/Restaurants/LuLu.htmlCarpe Diem on Elizabeth (in the Elizabeth neighborhood)
http://www.carpediemrestaurant.com has been around for a long time and has very solid food at reasonable prices. Down the street is Custom Shop which is supposed to be good but it opened just as we were leaving.
The Fig Tree is a more expensive restaurant in an old Arts and Crafts home with really good food.
http://www.charlottefigtree.comIf you're looking for a little local flavor (and aren't a vegetarian) you may want to hit the Penguin Drive in (it's not a drive in anymore)
http://www.penguindrivein.com -- Burgers (get it Southern Style), fried pickles, tatooed waitresses, etc. It's also in the Plaza Midwood neighborhood.
A new trendy spot at SouthPark is
http://www.harpersrestaurants.com/m5.html -- I've heard good things about it.
I haven't found a place in Louisville that serves what I consider "real" Italian food yet (not Italian-American) -- both Coco Osteria (downtown) and Il Posto (SouthPark) are very good.
http://www.cocoosteria.com/index.htmhttp://www.americascuisine.com/charlott ... steria.htmIf you're looking for a lunch place, my friends own a deli that is modeled after the Bagel and Deli in our college town (Oxford, OH) -- they steam the sandwiches so that all of the fillings melt together. It's really great (I like the Gandy Dancer). It's right next to downtown in the South End
http://www.owensbagelanddeli.com/index_ ... ge0001.htmETA: I forgot Cabo Fish Taco in NoDa (on North Davidson)
http://www.cabofishtaco.com/charlotte/index.htmlKeep in mind that even for the size of Charlotte, they don't have quite the restaurant culture of Louisville. If you need more help, let me know!
ps - There are Trader Joe's in Charlotte now, in case you're a fan.